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Acupuncture combined with traditional Chinese medicine in the treatment of premature ovarian failure:A meta-analysisFull-text in Chinese

Xu Yuanbo;Li Miaomiao;An Huiyan;Huang Zhenzhen;Li Miaomiao;Gao Yintong;Ni Jinxia;Dongzhimen Hospital, Beijing University of Chinese Medicine;Department of Acupuncture and Moxibustion, the First Medical Center, The General Hospital of the People’s Liberation Army;

Abstract:Objective To compare the efficacy and safety between acupuncture combined with traditional Chinese medicine and hormone replacement therapy for premature ovarian failure. Methods Articles up to October, 2019 about the randomized controlled trails on the efficacy of treating the premature ovarian failure with acupuncture combined with herbal medicine were included in the electronic retrieval library, which were from China national knowledge infrastructure(CNKI), China Science and Technology Journal Database(VIP), WanFang Database, China Biology Medicine disc(CBM), Pubmed, Cochrane Library, and EMBase. Studies screening and data extraction were performed by two researchers separately. The quality evaluation and risk assessment of the inclusion were carried out by using the criteria provided by the Cochrane. Meta-analysis was conducted with RevMan 5.3. Results A total of 14 randomized controlled trials were included, involving 879 individuals.The meta-analysis showed that:1) The total effective rate for the treatment of premature ovarian failure was higher in acupuncture combined with traditional Chinese medicine than in the hormone replacement therapy [OR=3.41,95% CI(2.38,4.89), P<0.05]; 2) The improvement of laboratory indexes(E2, FSH, LH) in patients who received treatment of acupuncture combined with traditional Chinese medicine were superior to those with hormone replacement therapy(SMD=0.86,-0.95,-0.82, P<0.05); 3) The improvement of the Kupperman score in patients with acupuncture combined with traditional Chinese medicine was superior to those with hormone replacement therapy(SMD=-0.99, P<0.05); 4) The main adverse reactions reported were gastrointestinal symptoms, dizziness and nausea.The adverse effects rate were similar in both oacupuncture combined with traditional Chinese medicine group and hormone replacement therapy group [OR=0.13, 95% CI(0.01,1.17), P=0.07].Conclusions Our analysis found that acupuncture combined with traditional Chinese medicine showed better efficacy than hormone replacement therapy in the treatment of premature ovarian failure. However, the quality of the enrolled studies is low. Consequently, more high-quality randomized controlled trials would be needed in future.
  • Series:

    (E) Medicine & Public Health

  • Subject:

    Traditional Chinese Medicine

  • Classification Code:

    R246.3

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