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Systematic Evaluation and Meta-analysis of Acupuncture-Moxibustion Alone in Treating Premature Ovarian FailureFull-text in Chinese

ZHANG Jin-Huan;LIU Yong-Feng;HUANG Xing-Xian;YU Hai-Bo;The Fourth Clinical Medical School of Guangzhou University of Chinese Medicine;Dept.of Acupuncture-Moxibustion,Shenzhen Traditional Chinese Medicine Hospital;

Abstract:Objective To systematically evaluate the clinical efficacy of acupuncture-moxibustion alone for the treatment of premature ovarian failure. Methods The literature about randomized control trials(RCTs) of acupuncture-moxibustion treatment for premature ovarian failure were searched out from CNKI,VIP,Wanfang,CBM,PubMed,Cochrane Library,and Embase databases. The included RCTs were given quality evaluation by Cochrane bias risk assessment tool. Meta-analysis was carried out by RevMan 5.3 software. Results A total of 16 literature according with standard were included, involving 1 102 cases of patients. The Mata-analysis results showed that the overall response rate of acupuncture-moxibustion treatment for premature ovarian failure was superior to that of the western medicine group [OR = 4.70,95% CI(3.34,6.61),P < 0.000 01]. Compared with the western medicine group,the acupuncture-moxibustion alone decreased follicle stimulating hormone(FSH)level [MD =-3.3,95% CI(-5.88,-0.72),P = 0.01],decreased luteinizing hormone(LH)level [MD =-5.81,95% CI(-7.42,-4.20),P < 0.000 01],and elevated estradiol(E2)level [MD = 24.15,95% CI(12.82,35.48),P < 0.000 1],showing that the effect was superior to that of the western medicine group. Conclusion Acupuncture-moxibustion alone treatment for premature ovarian failure is significantly effective for enhancing the response rate and improving hormone level,and has less adverse reactions. But due to the less sample size and lower quality of the included RCTs,the above results need to be verified by more large-scale and high-quality RCTs.
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  • Series:

    (E) Medicine & Public Health; (I) Electronic Technology & Information Science

  • Subject:

    Traditional Chinese Medicine; Computer Software and Application of Computer

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